KPV10mg
$80Lyophilized KPV supplied as a research reference standard.
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Example Certificate of Analysis
Certificate of Analysis
KPV
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
10mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for KPV; the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₁₆H₂₉N₃O₄ |
|---|---|
| CAS Number | 67727-97-3 |
| Molar Mass | 327.42 g/mol |
| Amino Acid Sequence | Lys-Pro-Val |
| Synonyms | Alpha-MSH (11-13), KPV tripeptide, α-MSH C-terminal tripeptide |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and DMSO |
| Organoleptic Profile | White to off-white lyophilized powder; odorless |
| Purity | ≥98% by HPLC |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 7 days |
How is KPV used in research?
KPV is a naturally occurring tripeptide consisting of lysine-proline-valine, derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). Despite being only three amino acids in length, KPV retains significant inflammatory-marker modulation activity in preclinical studies attributable to the parent hormone. Research has demonstrated that KPV exerts its effects primarily through inhibition of the NF-κB signaling pathway, a master regulator of inflammatory gene expression. This mechanism has been documented in multiple cell types including colonocytes, keratinocytes, and immune cells.
Preclinical studies have highlighted KPV's activity in gastrointestinal inflammation research models. Studies using murine colitis research models have shown that KPV can modulate inflammatory markers and attenuate tissue-damage readouts when administered orally or via nanoparticle delivery systems. The peptide has been shown to inhibit the activation of NF-κB by preventing the phosphorylation and degradation of IκBα, thereby reducing the transcription of pro-inflammatory cytokine markers including TNF-α, IL-1β, and IL-6.
Beyond gastrointestinal preclinical models, KPV has been investigated for its immunomodulatory properties in dermatological research models. Its parent peptide α-MSH is known to signal through melanocortin receptors, and KPV appears to retain some capacity to interact with these receptor pathways, contributing to its broad inflammatory-marker modulation profile across multiple tissue research models.
Areas of Study
Inflammatory-Marker Signaling
Investigated for potent inhibition of NF-κB pathway activation and downstream modulation of pro-inflammatory cytokine expression markers in multiple cell types.
Immune Modulation
Studied for modulation of innate and adaptive immune responses through melanocortin receptor-related pathways.
GI Epithelial Cell Models & Colitis Research
Preclinical colitis research models demonstrate modulation of intestinal inflammatory markers and tissue-damage readouts with oral or nanoparticle-delivered KPV.
NF-κB Signaling
Mechanistic studies reveal inhibition of IκBα phosphorylation and degradation, suppressing NF-κB nuclear translocation.
Dermatological Research
Investigated for inflammatory-marker modulation in skin cell-culture models through melanocortin receptor interactions.
References
- [1]Kannengiesser K, Maaser C, Heidemann J, et al. (2008). Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflammatory Bowel Diseases, 14(3), 324-331.
- [2]Brzoska T, Luger TA, Maaser C, et al. (2008). Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo. Endocrine Reviews, 29(5), 581-602.
- [3]Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 134(1), 166-178.
- [4]Luger TA, Brzoska T. (2007). Alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Annals of the Rheumatic Diseases, 66(Suppl 3), iii52-iii55.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of KPV is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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Frequently
Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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