ARA-29010mg
$90Lyophilized ARA-290 supplied as a research reference standard.
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Example Certificate of Analysis
Certificate of Analysis
ARA-290
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
10mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for ARA-290; the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₅₁H₈₄N₁₆O₂₁ |
|---|---|
| CAS Number | 1208243-50-8 |
| Molar Mass | 1257.34 g/mol |
| Amino Acid Sequence | Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Synonyms | ARA-290, Cibinetide, EPO-derived tissue-protective peptide |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and physiological saline |
| Organoleptic Profile | White lyophilized powder; odorless |
| Purity | ≥97% by HPLC |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 7 days |
How is ARA-290 used in research?
ARA-290 is an 11-amino acid synthetic peptide derived from a structural domain of erythropoietin, supplied as a lyophilized research standard for in-vitro receptor-binding assays and structural characterization. Not for use in any living organism.
Laboratory workflows profile ARA-290 in innate-repair-receptor (IRR) binding assays. The IRR is a heterodimer of the EPO receptor (EPOR) and the beta common receptor (CD131); this receptor signature is distinct from the erythropoietic EPOR homodimer, and in-vitro binding panels are used to characterize the selectivity of the 11-amino acid fragment. Functional readouts include cytoprotection markers in preclinical cell-culture stress assays and cytokine-marker panels (TNF-alpha, IL-6) in cultured immune-cell systems.
Researchers use ARA-290 as an analytical reference standard in HPLC and LC-MS identity and purity assays, as a structural reference in mass-spectrometry and circular-dichroism characterization, and as an IRR-selective reference ligand for comparability testing of novel EPO-derived peptide fragments.
Areas of Study
In-Vitro Receptor-Binding Assays
Used as a reference ligand in EPOR/CD131 heterodimer binding panels and EPOR homodimer selectivity controls.
Structural Characterization
Characterized by mass spectrometry and circular dichroism to confirm sequence identity and secondary-structure content of the 11-amino acid peptide.
Analytical Method Development
Applied as an identity and purity reference standard in HPLC and LC-MS comparability work.
Cytokine-Marker Panels
Profiled in cultured immune-cell systems for TNF-alpha and IL-6 marker readouts under standardized in-vitro stress conditions.
Cell-Culture Cytoprotection Assays
Used in in-vitro cytoprotection assays under controlled stress conditions in preclinical cell cultures.
References
- [1]Brines M, Patel NSA, Villa P, et al. (2008). Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proceedings of the National Academy of Sciences, 105(31), 10925-10930.
- [2]Brines M, Cerami A. (2012). The innate-repair receptor as a modulator of the innate immune response. Molecular Medicine, 18(1), 486-496.
- [3]Brines M, Grasso G, Fiordaliso F, et al. (2004). Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor. Proceedings of the National Academy of Sciences, 101(41), 14907-14912.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of ARA-290 is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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Frequently
Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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