Cagrilintide5mg–20mg
$100Lyophilized Cagrilintide supplied as a research reference standard.
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Example Certificate of Analysis
Certificate of Analysis
Cagrilintide
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
5mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for Cagrilintide; the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₁₉₄H₃₁₂N₅₄O₅₉S₂ |
|---|---|
| CAS Number | 1415456-99-3 |
| Molar Mass | 4409.00 g/mol |
| Amino Acid Sequence | Long-acting acylated amylin analog (37 amino acids with C18 fatty diacid modification) |
| Synonyms | Cagrilintide, AM833, NN9838 |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water at slightly acidic pH |
| Organoleptic Profile | White to off-white lyophilized powder; odorless |
| Purity | ≥97% by HPLC |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 7 days |
How is Cagrilintide used in research?
Cagrilintide is a long-acting, acylated analog of human amylin (islet amyloid polypeptide, IAPP) developed by Novo Nordisk for metabolic research applications. Native amylin is a 37-amino acid peptide co-secreted with insulin from pancreatic beta cells that acts as a satiety signal, slows gastric emptying, and suppresses postprandial glucagon secretion. Cagrilintide incorporates amino acid substitutions and a C18 fatty diacid side chain that extends its pharmacokinetic half-life in preclinical models, overcoming the rapid degradation that limits the preclinical utility of native amylin.
Preclinical research studies have characterized that cagrilintide produces dose-dependent body-composition parameter shifts in preclinical metabolic-parameter studies in rodent models. The peptide exerts its effects through activation of amylin receptors (AMY1, AMY2, AMY3), which are heterodimers of the calcitonin receptor with receptor activity-modifying proteins (RAMPs). Activation of these receptors in the area postrema and nucleus tractus solitarius of the brainstem reduces food-intake markers through central satiety signaling in preclinical models. Cagrilintide has also been investigated in combination with GLP-1 receptor agonist reference standards, which has shown additive body-composition parameter effects in research models.
Preclinical research has characterized cagrilintide's pharmacological profile across multiple amylin and calcitonin receptor subtypes. The molecule demonstrates potent agonism at amylin receptors with a selectivity profile designed to minimize calcitonin receptor-mediated effects. Research interest extends to preclinical metabolic-parameter effects beyond body-composition readouts, including glycemic-parameter markers and cardiovascular-risk research markers.
Areas of Study
Appetite Regulation
Activates brainstem amylin receptors to reduce food intake through central satiety signaling pathways in the area postrema and nucleus tractus solitarius.
Metabolic Research
Investigated for effects on glycemic-parameter markers, gastric-emptying, and postprandial glucagon suppression beyond body-composition parameter shifts in preclinical studies.
Amylin Signaling
Potent agonist at AMY1/AMY2/AMY3 receptor heterodimers with engineered selectivity to optimize preclinical profile.
Metabolic Research
Preclinical studies demonstrate dose-dependent effects on body weight and food intake; investigated as monotherapy and in combination with GLP-1 receptor agonists.
References
- [1]Mack CM, Soares CJ, Wilson JK, et al. (2010). Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight. International Journal of Obesity, 34(2), 385-395.
- [2]Lau DCW, Erichsen L, Francisco AM, et al. (2021). Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled trial. The Lancet, 398(10317), 2160-2172.
- [3]Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. (2015). Amylin: pharmacology, physiology, and clinical potential. Pharmacological Reviews, 67(3), 564-600.
- [4]Lutz TA. (2010). The role of amylin in the control of energy homeostasis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 298(6), R1475-R1484.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of Cagrilintide is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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