PT-14110mg
$80Lyophilized PT-141 supplied as a research reference standard.
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Example Certificate of Analysis
Certificate of Analysis
PT-141
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
10mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for PT-141; the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
|---|---|
| CAS Number | 189691-06-3 |
| Molar Mass | 1025.18 g/mol |
| Amino Acid Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (cyclic heptapeptide) |
| Synonyms | Bremelanotide, Vyleesi (brand), PT-141 |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and DMSO |
| Organoleptic Profile | White lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C |
| Composition | Lyophilized bremelanotide acetate salt |
How is PT-141 used in research?
PT-141, also known as bremelanotide, is a cyclic heptapeptide melanocortin receptor agonist derived from the synthetic alpha-melanocyte-stimulating hormone analog Melanotan II. Unlike phosphodiesterase inhibitors that act peripherally on vascular smooth muscle, bremelanotide acts centrally on the melanocortin system - specifically the melanocortin-4 receptor (MC4R) and melanocortin-3 receptor (MC3R) in the hypothalamus.
Mechanistically, MC4R activation in the medial preoptic area and paraventricular nucleus of the hypothalamus modulates neural circuits involved in sexual-behavior research, through downstream effects on oxytocin, dopamine, and other neurotransmitter systems. In preclinical models, bremelanotide has been characterized in sexual-behavior research models through a mechanism independent of peripheral vascular pathways.
Beyond sexual-behavior research, melanocortin receptor pharmacology is an active area of investigation with implications for energy-homeostasis research, inflammatory-marker modulation in preclinical studies, and neuroprotective assay models. MC4R plays a role in appetite regulation and energy balance research, and the melanocortin system is involved in modulation of inflammatory-marker responses through MC1R and MC3R. Preclinical research has investigated melanocortin analogs in hemorrhagic-shock, ischemia-reperfusion, and neuroinflammatory research models.
Areas of Study
Melanocortin Receptor Pharmacology
Studied as a tool compound for understanding MC3R and MC4R signaling in neural circuits controlling sexual behavior, appetite, and energy homeostasis.
Central Nervous System Mechanisms
Preclinical research explores bremelanotide's effects on hypothalamic oxytocin and dopamine release pathways underlying arousal and motivation.
Sexual Behavior Research
Investigated in preclinical models for effects on sexual behavior through central melanocortin receptor-mediated pathways independent of nitric oxide.
Inflammatory-Marker Modulation
Melanocortin receptor activation studied for modulation of inflammatory-marker responses through MC1R and MC3R in preclinical models.
Energy Homeostasis
MC4R's role in appetite regulation and energy balance makes melanocortin agonists subjects of metabolic research.
References
- [1]Hadley ME, Dorr RT. (2006). Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides, 27(4), 921-930.
- [2]Giuliano F, Rampin O, Allard J. (2002). Neurophysiology and pharmacology of female genital sexual response. Journal of Sex & Marital Therapy, 28(sup1), 101-121.
- [3]Van der Ploeg LH, Martin WJ, Howard AD, et al. (2002). A role for the melanocortin 4 receptor in sexual function. Proceedings of the National Academy of Sciences, 99(17), 11381-11386.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of PT-141 is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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Frequently
Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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