Kisspeptin10mg
$90Lyophilized Kisspeptin supplied as a research reference standard.
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Example Certificate of Analysis
Certificate of Analysis
Kisspeptin
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
10mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for Kisspeptin; the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₆₃H₈₃N₁₃O₁₄ |
|---|---|
| CAS Number | 374675-21-5 |
| Molar Mass | 1302.41 g/mol |
| Amino Acid Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ |
| Synonyms | Kisspeptin-10, Metastin (45-54), KP-10, KISS1 (112-121) |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and DMSO |
| Organoleptic Profile | White lyophilized powder; odorless |
| Purity | ≥98% by HPLC |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 7 days |
How is Kisspeptin used in research?
Kisspeptin-10 is the C-terminal decapeptide fragment of kisspeptin (also known as metastin), the endogenous ligand of the GPR54 (KISS1R) receptor. Kisspeptins are products of the KISS1 gene and play a central role in the neuroendocrine regulation of reproduction through stimulation of gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. The discovery of kisspeptin signaling in 2003 revolutionized reproductive neuroendocrinology by identifying the upstream signal responsible for activating the hypothalamic-pituitary-gonadal (HPG) axis at puberty and maintaining its function in adulthood.
Kisspeptin-10 retains full biological activity at the KISS1R receptor and is the minimal active fragment capable of stimulating GnRH release. Administration of kisspeptin-10 potently stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion across multiple species in research settings. Preclinical research has explored its use as a diagnostic tool for assessing HPG axis function and as a potential preclinical agent in models of reproductive dysfunction, including hypothalamic amenorrhea and hypogonadotropic hypogonadism.
Research has also revealed roles for kisspeptin signaling beyond reproduction, including regulation of placental function during pregnancy, modulation of metabolic pathways, and anti-metastatic activity (the KISS1 gene was originally identified as a metastasis suppressor). Studies continue to explore the preclinical potential of kisspeptin analogs in reproductive research, infertility research, and in vitro fertilization research protocols as alternatives to conventional GnRH agonist triggers.
Areas of Study
Reproductive Function
Central regulator of GnRH neuron activation; potently stimulates LH and FSH secretion for HPG axis assessment and preclinical modulation.
GnRH Signaling
Acts as the upstream activator of GnRH neurons via KISS1R (GPR54) receptor, the gateway signal for reproductive hormone release.
HPG Axis Research
Investigated as a diagnostic tool for HPG axis function and as a preclinical agent in hypogonadotropic conditions and hypothalamic amenorrhea.
Puberty Research
Kisspeptin signaling is the critical trigger for pubertal onset; loss-of-function mutations cause absent puberty in animal models.
Fertility & IVF Research
Explored as an alternative to GnRH agonists for oocyte maturation trigger in IVF protocols, with reduced ovarian hyperstimulation risk.
References
- [1]de Roux N, Genin E, Carel JC, et al. (2003). Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proceedings of the National Academy of Sciences, 100(19), 10972-10976.
- [2]Dhillo WS, Chaudhri OB, Patterson M, et al. (2005). Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. Journal of Clinical Endocrinology & Metabolism, 90(12), 6609-6615.
- [3]Seminara SB, Messager S, Chatzidaki EE, et al. (2003). The GPR54 gene as a regulator of puberty. New England Journal of Medicine, 349(17), 1614-1627.
- [4]Abbara A, Jayasena CN, Christopoulos G, et al. (2015). Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) therapy. Journal of Clinical Endocrinology & Metabolism, 100(9), 3322-3331.
- [5]Oakley AE, Clifton DK, Steiner RA. (2009). Kisspeptin signaling in the brain. Endocrine Reviews, 30(6), 713-743.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of Kisspeptin is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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Frequently
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Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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