Researchers studying TB-500 often combine
Save $45 with the BPC-157 + TB-500
All 2 compounds in a single lyophilized vial. Pre-blended at researcher-validated ratios for in-vitro co-incubation studies - no separate reconstitutions to manage.
Buying singles
- BPC-157 10mg$70
- TB-500 5mg$85
BPC-157 + TB-500
BPC 5mg + TB 5mg
TB-5005mg–10mg
$85Lyophilized TB-500 supplied as a research reference standard.
Secure
Ordering
Same-Day
Dispatch
Third Party
Tested
Batch & Lot
Tracking
Free Ship
Over $200
Based in
the USA
Secure checkout · ACH bank transfer saves 5%
Supplied to qualified labs and institutional buyers. Institutional use & eligibility
Frequently researched together
GLP-3 RT
20mg
$150
KLOW
80mg
$195
CJC-1295 + Ipamorelin
10mg + 10mg
$190
Bundle total
$535
Researchers also viewed
View all
Example Certificate of Analysis
Certificate of Analysis
TB-500
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
5mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for TB-500; the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
|---|---|
| CAS Number | 77591-33-4 |
| Molar Mass | 4963.44 g/mol |
| Amino Acid Sequence | 43-amino acid fragment of Thymosin Beta-4 (Tβ4) |
| Synonyms | Thymosin Beta-4 fragment, Tβ4, TB4 |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in aqueous buffer; reconstitute for in-vitro laboratory use only |
| Organoleptic Profile | White lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 10 days |
| Composition | Lyophilized Thymosin Beta-4 acetate salt |
How is TB-500 used in research?
TB-500 is a synthetic version of the naturally occurring 43-amino acid peptide Thymosin Beta-4 (Tβ4), which is found in virtually all mammalian cells. Thymosin Beta-4 plays a fundamental role in cellular processes including actin polymerization, cell migration, and differentiation. As the primary intracellular G-actin sequestering peptide, it regulates actin dynamics that are critical for cell motility, organogenesis, and tissue-repair research models. Research interest in TB-500 centers on its activity in in-vitro wound-assay outcomes, inflammatory-marker modulation in preclinical studies, and tissue-remodeling research models.
Preclinical studies have characterized Thymosin Beta-4 in dermal and corneal epithelial cell-culture models, cardiac research models following myocardial ischemia induction, and central nervous system preclinical research models. The peptide upregulates the expression of laminin-5, a key component of the extracellular matrix, and promotes the migration of endothelial cells and keratinocytes in cell-migration kinetics studies. In cardiac preclinical research, Tβ4 has been shown to activate epicardium-derived progenitor cells and to modulate infarct-size parameters in rodent research models.
Additional research has explored TB-500's inflammatory-marker modulation profile. The peptide has been reported to downregulate pro-inflammatory cytokine markers and to modulate NF-κB signaling pathways. Studies in equine research models have investigated its effects on tendon and ligament preclinical-model parameters, while ophthalmic research has examined its activity in corneal epithelial cell-culture models. These findings suggest a multifaceted mechanism of action extending across multiple tissue-repair research models.
Areas of Study
In-Vitro Wound-Assay Outcomes
Examined in dermal wound-closure assays through upregulation of laminin-5 and promotion of endothelial-cell and keratinocyte migration kinetics.
Cardiac Research Models
Investigated for infarct-size parameter modulation and activation of epicardium-derived progenitor cells in myocardial ischemia research models.
Inflammatory-Marker Modulation
Research demonstrates downregulation of pro-inflammatory cytokine markers and modulation of NF-κB signaling pathways in preclinical studies.
Corneal Epithelial Cell-Culture Models
Studied in corneal epithelial cell-culture models and inflammatory-marker modulation in ophthalmic preclinical research.
Musculoskeletal Research Models
Examined for activity in tendon and ligament tissue-repair research models through modulation of extracellular matrix deposition and cellular migration.
References
- [1]Goldstein AL, Hannappel E, Sosne G, Kleinman HK. (2012). Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opinion on Biological Therapy, 12(1), 37-51.
- [2]Sosne G, Qiu P, Goldstein AL, Wheater M. (2010). Biological activities of thymosin β4 defined by active sites in short peptide sequences. FASEB Journal, 24(7), 2144-2151.
- [3]Bock-Marquette I, Saxena A, White MD, et al. (2004). Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466-472.
- [4]Philp D, Huff T, Gho YS, et al. (2003). The actin binding site on thymosin β4 promotes angiogenesis. FASEB Journal, 17(14), 2103-2105.
- [5]Smart N, Risebro CA, Melville AA, et al. (2007). Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 445(7124), 177-182.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of TB-500 is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
View COAsMore research compounds
View all
Frequently
Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
Ready to Start
Your Research?
Browse the complete catalog of third-party verified, lyophilized research compounds. Orders before 2PM EST ship same day.