DSIP5mg–10mg
$65Lyophilized DSIP supplied as a research reference standard.
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Example Certificate of Analysis
Certificate of Analysis
DSIP
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
5mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for DSIP; the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
|---|---|
| CAS Number | 62568-57-4 |
| Molar Mass | 848.82 g/mol |
| Amino Acid Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Synonyms | Delta Sleep-Inducing Peptide, DSIP, Emideltide |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and dilute acetic acid |
| Organoleptic Profile | White lyophilized powder; odorless |
| Purity | ≥98% by HPLC |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 7 days |
How is DSIP used in research?
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated from the cerebral venous blood of rabbits during electrically induced sleep by Schoenenberger and Monnier in 1977. The peptide consists of nine amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) and has been identified in various brain regions as well as peripheral tissues. DSIP is notable for its amphiphilic properties, which allow it to cross the blood-brain barrier, and for its remarkably diverse range of reported biological activities extending well beyond sleep modulation.
Research into DSIP's effects on slow-wave EEG markers has produced mixed but intriguing results. Some studies have demonstrated increases in delta (slow-wave) sleep in animal research models and research systems, while others have reported more nuanced effects on sleep-wake cycling and circadian phase adjustment in preclinical models. Beyond sleep, DSIP has been investigated for its role in stress-response modulation, with studies showing attenuation of stress-induced metabolic and endocrine markers in preclinical models. The peptide appears to modulate hypothalamic-pituitary-adrenal (HPA) axis activity and has been reported to normalize cortisol and ACTH markers under stress conditions in research models.
Additional research has explored DSIP's effects on pain-perception research readouts, with some studies suggesting analgesic-assay activity mediated through opioid receptor interactions. The peptide has also been investigated for its antioxidant-assay activity and its modulation of free-radical metabolism markers, which has generated interest in neuroprotective assay model research.
Areas of Study
Sleep Regulation
Originally isolated as a sleep-promoting factor; investigated for modulation of delta-wave (slow-wave) EEG markers in preclinical models.
Circadian Rhythm Modulation
Studied for effects on circadian phase adjustment and normalization of disrupted sleep-wake cycles.
Stress Response
Research demonstrates attenuation of stress-induced metabolic and endocrine disturbances through HPA axis modulation.
Neuroendocrine Regulation
Investigated for normalization of cortisol, ACTH, and other neuroendocrine markers under physiological and pathological stress conditions.
References
- [1]Schoenenberger GA, Monnier M. (1977). Characterization of a delta-electroencephalogram (sleep)-inducing peptide. Proceedings of the National Academy of Sciences, 74(3), 1282-1286.
- [2]Graf MV, Kastin AJ. (1984). Delta-sleep-inducing peptide (DSIP): a review. Neuroscience & Biobehavioral Reviews, 8(1), 83-93.
- [3]Prudchenko IA, Stashevskaya LV, Mikhaleva II, Ivanov VT. (1994). Delta sleep-inducing peptide: structural analogues and immunoreactive analogues. Bioorganic Chemistry, 20(10-11), 1046-1058.
- [4]Kovalzon VM, Strekalova TV. (2006). Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Journal of Neurochemistry, 97(2), 303-309.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of DSIP is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
View COAsFrequently
Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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